In a world still suffering from the COVID-19 pandemic, immunology, infectious disease testing, and vaccine development have never been more relevant to the public discourse. This COVID-19 and Digital Update of Kuby Immunology adds COVID-19-relevant content through the text and support in Achieve, Macmillan’s next-generation online learning system. Achieve offers powerful multimedia assets, active learning activities, and assessment tools to support immunology students and instructors.